|
KMID : 1161420150180121380
|
|
Journal of Medicinal Food
2015 Volume.18 No. 12 p.1380 ~ p.1386
|
|
|
Apple Pomace Extract Improves Endurance in Exercise Performance by Increasing Strength and Weight of Skeletal Muscle
|
|
Jeong Ji-Woong
Shim Jae-Jung
Choi Il-Dong
Kim Sung-Hwan
Ra Je-Hyeon
Ku Hyung-Keun
Lee Dong-Eun
Kim Tae-Youl
Jeung Woon-Hee
Lee Jung-Hee
Lee Ki-Won
Huh Chul-Sung
Sim Jae-Hun
Ahn Young-Tae
|
|
|
Abstract
|
|
|
|
Ursolic acid is a lipophilic pentacyclic triterpenoid found in many fruits and herbs and is used in several herbal folk medicines for diabetes. In this study, we evaluated the effects of apple pomace extract (APE; ursolic acid content, 183?mg/g) on skeletal muscle atrophy. To examine APE therapeutic potential in muscle atrophy, we investigated APE effects on the expression of biomarkers associated with muscle atrophy and hypertrophy. We found that APE inhibited atrophy, while inducing hypertrophy in C2C12 myotubes by decreasing the expression of atrophy-related genes and increasing the expression of hypertrophy-associated genes. The in vivo experiments using mice fed a diet with or without APE showed that APE intake increased skeletal muscle mass, as well as grip strength and exercise capacity. In addition, APE significantly improved endurance in the mice, as evidenced by increased exhaustive running time and muscle weight, and reduced the expression of the genes involved in the development of muscle atrophy. APE also decreased the concentration of serum lactate and lactate dehydrogenase, inorganic phosphate, and creatinine, the indicators of accumulated fatigue and exercise-induced stress. These results suggest that APE may be useful as an ergogenic functional food or dietary supplement.
|
|
|
KEYWORD
|
|
|
apple pomace, atrophy, muscle strength, ursolic acid
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|